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Of course, therapeutic blood concentrations may still be reached by the oral route of administration if larger doses are given

At clinical doses under supervision, the most common side effects are mild nausea in the first week (typically resolves by day 7 to 10), injection site reactions (redness, minor swelling, localized soreness lasting 24 hours), and occasional transient fatigue or mild headache in the first few days

[DOI] [PubMed] [Google Scholar] 134.Inouye H, Houde D, Temel DB, Makowski L

Nonetheless, long-range repulsion may not be sufficient to prevent chargecharge interactions since antibodies are comprised of a multidomain structure, whose different domains may be oppositely charged, and form local intermolecular electrostatic attractions